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Article

Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis.

Carcinogenesis - 1 Jun 2010

Miermont Anne M, Parrish Angela R, Furth Priscilla A

Abstract excerpt

Deregulated estrogen signaling is evidently linked to breast cancer pathophysiology, although the role of signal transducer and activator of transcription (Stat)5a, integral to normal mammary gland development, is less clear. A mouse model of mammary epithelial cell-targeted deregulated estrogen receptor alpha (ERalpha) expression [conditional ERalpha in mammary epithelium (CERM)] was crossed with mice carrying a...

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Identifiers

PMID: 20181624
DOI: 10.1093/carcin/bgq048
PMCID: PMC2878361

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