Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hsp90 depletion goes wild.

BMC biology - 27 Feb 2012

Siegal Mark L, Masel Joanna

Abstract excerpt

Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Saccharomyces cerevisiae Proteins
Share to Down-Regulation
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Fertility

Share to Heat-Shock Proteins

Share to HSP90 Heat-Shock Proteins

Share to Longevity

Source

Open in PubMed Open full text

Identifiers

PMID: 22369621
DOI: 10.1186/1741-7007-10-14
PMCID: PMC3287126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hsp90 depletion goes wild.PMID 22369621Read ↗

The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis.Semantic proximity Read ↗

Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations.Semantic proximity Read ↗

Modularity and intrinsic evolvability of Hsp90-buffered change.Semantic proximity Read ↗

Quantitative trait symmetry independent of Hsp90 buffering: distinct modes of genetic canalization and developmental stability.Semantic proximity Read ↗

Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons.Semantic proximity Read ↗

HSP90 buffers newly induced mutations in massively mutated plant linesSemantic proximity Read ↗

Hsp90 as a capacitor for morphological evolution.Semantic proximity Read ↗

It's not magic - Hsp90 and its effects on genetic and epigenetic variation.Semantic proximity Read ↗

Control of canalization and evolvability by Hsp90.Semantic proximity Read ↗

Hsp90 and developmental networks.Semantic proximity Read ↗

Transposons, environmental changes, and heritable induced phenotypic variability.Semantic proximity Read ↗

Hsp90 and environmental stress transform the adaptive value of natural genetic variation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.