Article
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
Science (New York, N.Y.) - 24 Dec 2010
Jarosz Daniel F, Lindquist Susan
Abstract excerpt
How can species remain unaltered for long periods yet also undergo rapid diversification? By linking genetic variation to phenotypic variation via environmental stress, the Hsp90 protein-folding reservoir might promote both stasis and change. However, the nature and adaptive value of Hsp90-contingent traits remain uncertain. In ecologically and genetically diverse yeasts, we find such traits to be both common and...
Topics
- Adaptation, Physiological
- Biological Evolution
- Crosses, Genetic
- Deoxycholic Acid
- Drug Resistance, Fungal
- Genetic Variation
- HSP90 Heat-Shock Proteins
- Hydroxyurea
- Intracellular Signaling Peptides and Proteins
- Microtubule-Associated Proteins
- Mitochondrial Proteins
- Open Reading Frames
- Polymorphism, Genetic