Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hsp90 as a capacitor for morphological evolution.

Nature - 26 Nov 1998

Rutherford S L, Lindquist S

Abstract excerpt

The heat-shock protein Hsp90 supports diverse but specific signal transducers and lies at the interface of several developmental pathways. We report here that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with...

Topics

Animals
Directed Molecular Evolution
Drosophila
Drosophila Proteins
Genetic Variation
HSP90 Heat-Shock Proteins
Heat-Shock Proteins
Models, Genetic
Mutation
Phenotype
Temperature

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9845070
DOI: 10.1038/24550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9845070-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hsp90 as a capacitor for morphological evolution.PMID 9845070Read ↗

Modularity and intrinsic evolvability of Hsp90-buffered change.Semantic proximity Read ↗

The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis.Semantic proximity Read ↗

Quantitative trait symmetry independent of Hsp90 buffering: distinct modes of genetic canalization and developmental stability.Semantic proximity Read ↗

Hsp90 and developmental networks.Semantic proximity Read ↗

Hsp90 as a capacitor of phenotypic variation.Semantic proximity Read ↗

It's not magic - Hsp90 and its effects on genetic and epigenetic variation.Semantic proximity Read ↗

Control of canalization and evolvability by Hsp90.Semantic proximity Read ↗

A naturally occurring variant of Hsp90 that is associated with decanalization.Semantic proximity Read ↗

Waddington's widget: Hsp90 and the inheritance of acquired characters.Semantic proximity Read ↗

Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution.Semantic proximity Read ↗

Molecular mechanisms of canalization: Hsp90 and beyond.Semantic proximity Read ↗

Incapacitating the evolutionary capacitor: Hsp90 modulation of disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.