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Article

The role of Irf6 in tooth epithelial invagination.

Developmental biology - 1 May 2012

Blackburn James, Ohazama Atsushi, Kawasaki Katsushige, Otsuka-Tanaka Yoko, Liu Bigang, Honda Kenya, Rountree Ryan B, Hu Yinling, Kawasaki Maiko, Birchmeier Walter, Schmidt-Ullrich Ruth, Kinoshita Akira, Schutte Brian C, Hammond Nigel L, Dixon Michael J, Sharpe Paul T

Abstract excerpt

Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikkα has been shown to play a critical role in controlling epithelial growth, since Ikkα mutant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rather than invagination. We show here that mutation of the Interferon regulatory factor (Irf) family,...

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Identifiers

PMID: 22366192
DOI: 10.1016/j.ydbio.2012.02.009
PMCID: PMC7462630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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