Article
Full Spectrum of Postnatal Tooth Phenotypes in a Novel Irf6 Cleft Lip Model.
Journal of dental research - 1 Oct 2016
Chu E Y, Tamasas B, Fong H, Foster B L, LaCourse M R, Tran A B, Martin J F, Schutte B C, Somerman M J, Cox T C
Abstract excerpt
Clefting of the lip, with or without palatal involvement (CLP), is associated with a higher incidence of developmental tooth abnormalities, including hypodontia and supernumerary teeth, aberrant crown and root morphologies, and enamel defects, although the underlying mechanistic link is poorly understood. As most CLP genes are expressed throughout the oral epithelium, the authors hypothesized that the expression...
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