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Article

IRF6 expression in basal epithelium partially rescues Irf6 knockout mice.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2017

Kousa Youssef A, Moussa Dina, Schutte Brian C

Abstract excerpt

BACKGROUND: Mutations in IRF6, CHUK (IKKA), and RIPK4 can lead to a disease spectrum that includes cutaneous, limb, and craniofacial malformations. Loss of these alleles in the mouse leads to perinatal lethality and severe cutaneous, limb, and craniofacial defects also. Genetic rescue in the mouse has been shown for Ikka and Ripk4. RESULTS: Here, we show partial genetic rescue of Irf6 knockout embryos using the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28643456
DOI: 10.1002/dvdy.24537
PMCID: PMC5552062

Genes

KRT14
RIPK4
CHUK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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