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Article

Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development.

Scientific reports - 2 Aug 2017

Fakhouri Walid D, Metwalli Kareem, Naji Ali, Bakhiet Sarah, Quispe-Salcedo Angela, Nitschke Larissa, Kousa Youssef A, Schutte Brian C

Abstract excerpt

Interferon Regulatory Factor 6 (IRF6) and TWIST1 are transcription factors necessary for craniofacial development. Human genetic studies showed that mutations in IRF6 lead to cleft lip and palate and mandibular abnormalities. In the mouse, we found that loss of Irf6 causes craniosynostosis and mandibular hypoplasia. Similarly, mutations in TWIST1 cause craniosynostosis, mandibular hypoplasia and cleft palate....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28769044
DOI: 10.1038/s41598-017-06310-z
PMCID: PMC5540929

Genes

TWIST1
EDN1
DLX5
DLX6
HAND2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development.PMID 28769044Read ↗

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