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Article

Murine IRF8 Mutation Offers New Insight into Osteoclast and Root Resorption.

Journal of dental research - 1 Mar 2024

Das A, Yesupatham S K, Allison D, Tanwar H, Gnanasekaran J, Kear B, Wang X, Wang S, Zachariadou C, Abbasi Y, Chung M K, Ozato K, Liu C, Foster B L, Thumbigere-Math V

Abstract excerpt

Interferon regulatory factor 8 (IRF8), a transcription factor expressed in immune cells, functions as a negative regulator of osteoclasts and helps maintain dental and skeletal homeostasis. Previously, we reported that a novel mutation in the IRF8 gene increases susceptibility to multiple idiopathic cervical root resorption (MICRR), a form of tooth root resorption mediated by increased osteoclast activity. The...

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Identifiers

PMID: 38343385
DOI: 10.1177/00220345231222173
PMCID: PMC10985390

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