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Article

IRF6 and SPRY4 Signaling Interact in Periderm Development.

Journal of dental research - 1 Oct 2017

Kousa Y A, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, Klein O D, Schutte B C

Abstract excerpt

Rare mutations in IRF6 and GRHL3 cause Van der Woude syndrome, an autosomal dominant orofacial clefting disorder. Common variants in IRF6 and GRHL3 also contribute risk for isolated orofacial clefting. Similarly, variants within genes that encode receptor tyrosine kinase (RTK) signaling components, including members of the FGF pathway, EPHA3 and SPRY2, also contribute risk for isolated orofacial clefting. In the...

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Share to Abnormalities, Multiple
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28732181
DOI: 10.1177/0022034517719870
PMCID: PMC5613880

Genes

GRHL3
SPRY4
EPHA3
SPRY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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IRF6 and SPRY4 Signaling Interact in Periderm Development.PMID 28732181Read ↗

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