Article
Pelota controls self-renewal of germline stem cells by repressing a Bam-independent differentiation pathway.
Development (Cambridge, England) - 1 Dec 2005
Xi Rongwen, Doan Choung, Liu Dazhi, Xie Ting
Abstract excerpt
In the Drosophila ovary, germline stem cell (GSC) self-renewal is controlled by both extrinsic and intrinsic factors. The Bmp signal from niche cells controls GSC self-renewal by directly repressing a Bam-dependent differentiation pathway in GSCs. pelota (pelo), which has been previously shown to be required for Drosophila male meiosis, was identified in our genetic screen as a dominant suppressor of the dpp...
Topics
- Animals
- Cell Differentiation
- Cytoplasm
- Drosophila
- Drosophila Proteins
- Female
- Germ Cells
- Male
- Meiosis
- Mitosis
- Mutation
- Nuclear Proteins