Article
Drug sensitivity of heat-resistant mouse B16 melanoma variants.
Radiation research - 1 Oct 1990
Kroll D J, Borgert C J, Wiedmann T W, Rowe T C
Abstract excerpt
Induction of transient thermotolerance by heat or other cytotoxic stressors has been reported to confer a moderate degree of drug resistance to tumor cells in vitro. In this study, a genetically stable, heat-resistant mouse B16 melanoma variant (W-H75) was tested for its sensitivity to various cy...
Topics
- Acclimatization
- Animals
- Antineoplastic Agents
- Cell Line
- DNA, Neoplasm
- DNA, Single-Stranded
- Daunorubicin
- Doxorubicin
- Drug Tolerance
- Etoposide
- Genetic Variation
- Hot Temperature
- In Vitro Techniques
- Melanoma, Experimental
- Mice
- Tumor Cells, Cultured