Article
p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
Oncology reports - 1 Jan 2010
Fujii Yoshihiro, Kato Takamitsu, Kubota Nobuo, Fujimori Akira, Niwa Ohtsura, Okayasu Ryuichi
Abstract excerpt
Inhibition of heat shock protein 90 (Hsp90) is an attractive modality for cancer therapy. Recent studies presented that an Hsp90 inhibitor, 17AAG (17-allylamino-17-demethoxygeldanamycin), enhanced tumor radio-sensitivity, while this was not observed in normal cells. One of the studies reported th...
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