Article
Metastasis-associated mts1 gene expression is down-regulated by heat shock in variant cell lines of the B16 murine melanoma.
Melanoma research - 1 Jun 1994
Cajone F, Debiasi S, Parker C, Lakshmi M S, Sherbet G V
Abstract excerpt
Tumour cells are more heat sensitive than corresponding normal cells but the reasons for this are poorly understood. Here we report that induction of heat shock proteins was associated with a down-regulation of the metastasis associated mts1 gene in BL6-B16 murine melanoma cells, and the heat-res...
Topics
- Animals
- Cell Division
- Cell Line
- Clone Cells
- Gene Expression Regulation, Neoplastic
- Genetic Variation
- Heat-Shock Proteins
- Hot Temperature
- Melanoma, Experimental
- Methionine
- Mice
- Neoplasm Metastasis
- Paclitaxel
- Sulfur Radioisotopes
- Tretinoin
- alpha-MSH