Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines.

PloS one - 1 Jan 2012

Justiniano Steven E, Mathew Anne, Mitra Sayan, Manivannan Sathiya N, Simcox Amanda

Abstract excerpt

In vivo analysis of Drosophila melanogaster has enhanced our understanding of many biological processes, notably the mechanisms of heredity and development. While in vivo analysis of mutants has been a strength of the field, analyzing fly cells in culture is valuable for cell biological, biochemi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Assay
Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperplasia

Share to Mutant Proteins

Share to PTEN Phosphohydrolase

Share to ras Proteins

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22363644
DOI: 10.1371/journal.pone.0031417
PMCID: PMC3283623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22363644-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines.PMID 22363644Read ↗

Efficient genetic method for establishing Drosophila cell lines unlocks the potential to create lines of specific genotypes.Semantic proximity Read ↗

Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues.Semantic proximity Read ↗

Drosophila embryonic 'fibroblasts': extending mutant analysis in vitro.Semantic proximity Read ↗

Clonal effects of the <i>Ras</i> oncogene revealed by somatic mutagenesis in a <i>Drosophila</i> cancer modelSemantic proximity Read ↗

Prp8 regulates oncogene-induced hyperplastic growth in Drosophila.Semantic proximity Read ↗

A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation.Semantic proximity Read ↗

Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in <i>Drosophila</i>Semantic proximity Read ↗

Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster.Semantic proximity Read ↗

A genetic screen in Drosophila for metastatic behavior.Semantic proximity Read ↗

PTEN affects cell size, cell proliferation and apoptosis during <i>Drosophila</i> eye developmentSemantic proximity Read ↗

Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila.Semantic proximity Read ↗

Using the Drosophila melanogaster D17-c3 cell culture system to study cell motility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.