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Article

PTEN affects cell size, cell proliferation and apoptosis during <i>Drosophila</i> eye development

1 Dec 1999

Abstract excerpt

Mutations in the tumor suppressor gene PTEN (MMAC1/TEP1) are associated with a large number of human cancers and several autosomal-dominant disorders. Mice mutant for PTEN die at early embryonic stages and the mutant embryonic fibroblasts display decreased sensitivity to cell death. Overexpression of PTEN in different mammalian tissue culture cells affects various processes including cell proliferation, cell...

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PMID: 10556061
DOI: 10.1242/dev.126.23.5365

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