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Article

Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism

1 Sept 2015

Abstract excerpt

Genomic instability and altered metabolism are key features of most cancers. Recent studies suggest that metabolic reprogramming is part of a systematic response to cellular DNA damage. Thus, defining the molecules that fine-tune metabolism in response to DNA damage will enhance our understanding of molecular mechanisms of tumorigenesis and have profound implications for the development of strategies for cancer...

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Identifiers

PMID: 26420294
DOI: 10.14348/molcells.2015.0167

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