Article
Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.
PLoS medicine - 1 Feb 2012
Clarke Robert, Bennett Derrick A, Parish Sarah, Verhoef Petra, Dötsch-Klerk Mariska, Lathrop Mark, Xu Peng, Nordestgaard Børge G, Holm Hilma, Hopewell Jemma C, Saleheen Danish, Tanaka Toshihiro, Anand Sonia S, Chambers John C, Kleber Marcus E, Ouwehand Willem H, Yamada Yoshiji, Elbers Clara, Peters Bas, Stewart Alexandre F R, Reilly Muredach M, Thorand Barbara, Yusuf Salim, Engert James C, Assimes Themistocles L, Kooner Jaspal, Danesh John, Watkins Hugh, Samani Nilesh J, Collins Rory, Peto Richard
Abstract excerpt
BACKGROUND: Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an...
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