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Three genetic polymorphisms of homocysteine-metabolizing enzymes and risk of coronary heart disease: a meta-analysis based on 23 case-control studies.

DNA and cell biology - 1 Feb 2012

Chen Ling, Liu Liu, Hong Kui, Hu Jianxin, Cheng Xiaoshu

Abstract excerpt

Many epidemiological studies have explored the relationships between three genetic polymorphisms of genes encoding homocysteine-metabolizing enzymes (methionine synthase [MTR] A2756G, methionine synthase reductase [MTRR] A66G, and N(5),N(10)-methylenetetrahydrofolate reductase [MTHFR] A1298C) and risk of coronary heart disease (CHD), but no conclusive results were obtained. Therefore, we performed a meta-analysis...

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5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Algorithms
Coronary Disease
Ferredoxin-NADP Reductase
Homocysteine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolic Networks and Pathways

Methylenetetrahydrofolate Reductase (NADPH2)

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PMID: 21780915
DOI: 10.1089/dna.2011.1281

Genes

MTR
MTHFR
MTRR

Variants

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