Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis.

PloS one - 2 Feb 2011

Wald David S, Morris Joan K, Wald Nicholas J

Abstract excerpt

BACKGROUND: Results from genetic epidemiological studies suggest that raised serum homocysteine is a cause of ischaemic heart disease, but the results of randomised trials suggest otherwise. We aimed to update meta-analyses on each type of study using the latest published data and test a hypothesis based on antiplatelet therapy use in the trials to explain the discrepancy. METHODS AND FINDINGS: Meta-analyses of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Homocysteine
Share to Methylenetetrahydrofolate Reductase (NADPH2)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocardial Ischemia

Share to Polymorphism, Single Nucleotide

Share to Prevalence

Share to Randomized Controlled Trials as Topic

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21311765
DOI: 10.1371/journal.pone.0016473
PMCID: PMC3032783

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis.PMID 21311765Read ↗

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis.Semantic proximity Read ↗

MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification.Semantic proximity Read ↗

Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.Semantic proximity Read ↗

Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?Semantic proximity Read ↗

Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements.Semantic proximity Read ↗

MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.Semantic proximity Read ↗

Homocysteine Determinants and the Evidence to What Extent Homocysteine Determines the Risk of Coronary Heart DiseaseSemantic proximity Read ↗

The homocysteine controversySemantic proximity Read ↗

Homocysteine and ischaemic heart disease.Semantic proximity Read ↗

Three genetic polymorphisms of homocysteine-metabolizing enzymes and risk of coronary heart disease: a meta-analysis based on 23 case-control studies.Semantic proximity Read ↗

Homocysteine and carotid intima-media thickness: a critical appraisal of the evidenceSemantic proximity Read ↗

5,10-methylenetetrahydrofolate reductase C677T gene polymorphism and peripheral arterial disease: A meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.