Article
Cardiovascular phenotype of the Dmdmdx rat - a suitable animal model for Duchenne muscular dystrophy.
Disease models & mechanisms - 22 Feb 2021
Szabó Petra Lujza, Ebner Janine, Koenig Xaver, Hamza Ouafa, Watzinger Simon, Trojanek Sandra, Abraham Dietmar, Todt Hannes, Kubista Helmut, Schicker Klaus, Remy Séverine, Anegon Ignacio, Kiss Attila, Podesser Bruno K, Hilber Karlheinz
Abstract excerpt
Besides skeletal muscle abnormalities, Duchenne muscular dystrophy (DMD) patients present with dilated cardiomyopathy development, which considerably contributes to morbidity and mortality. Because the mechanisms responsible for the cardiac complications in the context of DMD are largely unknown, evidence-based therapy approaches are still lacking. This has increased the need for basic research efforts into...
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