Increased oxidative stress and Ca MKII activity contribute to electro‐mechanical defects in cardiomyocytes from a murine model of Huntington's disease

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative genetic disorder. Although described as a brain pathology, there is evidence suggesting that defects in other systems can contribute to disease progression. In line with this, cardiovascular defects are a major cause of death in HD. To date, relatively little is known about the peripheral abnormalities associated with the disease. Here, we applied a range of assays...

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