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Article

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage.

Scientific reports - 16 May 2016

Chen Chia-Ling, Wu Yueh-Ying, Lin Chiou-Feng, Kuo Chih-Feng, Han Chia-Li, Wang Shuying, Chuang Woei-Jer, Chen Chiu-Yueh, Wu Jiunn-Jong, Tsai Pei-Jane, Liu Ching-Chuan, Lin Yee-Shin

Abstract excerpt

Clearance of apoptotic cells by macrophages plays an important role in maintaining tissue homeostasis. Previous study indicated that streptococcal pyrogenic exotoxin B (SPE B) reduces phagocytic activity in group A streptococcus (GAS) infection. Here, we demonstrate that SPE B causes an inhibitory effect on protein S-mediated phagocytosis. In the presence of SPE B, serum- and purified protein S-mediated...

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Share to Cysteine Endopeptidases
Share to Macrophages, Peritoneal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27181595
DOI: 10.1038/srep26026
PMCID: PMC4867609

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