Article
Peripheral nerve injury induces Schwann cells to express two macrophage phenotypes: phagocytosis and the galactose-specific lectin MAC-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 1994
Reichert F, Saada A, Rotshenker S
Abstract excerpt
In N mice, peripheral nerve injury is followed by the normal rapid progression of Wallerian degeneration: Schwann cells proliferate and lose their myelin, which is phagocytized and metabolized by blood-borne macrophages. The role of Schwann cells in myelin phagocytosis is debated. Additionally, t...
Topics
- Animals
- Antigens, Differentiation
- Galactose
- Galectin 3
- Lactose
- Macrophage-1 Antigen
- Macrophages
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Myelin Sheath
- Nerve Degeneration
- Peripheral Nerve Injuries
- Peripheral Nerves
- Phagocytosis
- Phenotype
- Receptors, Fc
- Reference Values