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Article

Unique domain appended to vertebrate tRNA synthetase is essential for vascular development.

Nature communications - 21 Feb 2012

Xu Xiaoling, Shi Yi, Zhang Hui-Min, Swindell Eric C, Marshall Alan G, Guo Min, Kishi Shuji, Yang Xiang-Lei

Abstract excerpt

New domains were progressively added to cytoplasmic aminoacyl transfer RNA (tRNA) synthetases during evolution. One example is the UNE-S domain, appended to seryl-tRNA synthetase (SerRS) in species that developed closed circulatory systems. Here we show using solution and crystal structure analyses and in vitro and in vivo functional studies that UNE-S harbours a robust nuclear localization signal (NLS) directing...

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Share to Active Transport, Cell Nucleus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Physiologic

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Share to Vascular Endothelial Growth Factor A

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Source

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Identifiers

PMID: 22353712
DOI: 10.1038/ncomms1686
PMCID: PMC3293412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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