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Article

Structural analyses of a human lysyl-tRNA synthetase mutant associated with autosomal recessive nonsyndromic hearing impairment.

Biochemical and biophysical research communications - 21 May 2021

Wu Siqi, Hei Zhoufei, Zheng Li, Zhou Jintong, Liu Zaizhou, Wang Jing, Fang Pengfei

Abstract excerpt

Aminoacyl-tRNA synthetases (AARSs) catalyze the ligation of amino acids to their cognate tRNAs and therefore play an essential role in protein biosynthesis in all living cells. The KARS gene in human encodes both cytosolic and mitochondrial lysyl-tRNA synthetase (LysRS). A recent study identified a missense mutation in KARS gene (c.517T > C) that caused autosomal recessive nonsyndromic hearing loss. This mutation...

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PMID: 33784510
DOI: 10.1016/j.bbrc.2021.03.093

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