Article
ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase.
Nature - 1 May 2018
Vo My-Nuong, Terrey Markus, Lee Jeong Woong, Roy Bappaditya, Moresco James J, Sun Litao, Fu Hongjun, Liu Qi, Weber Thomas G, Yates John R, Fredrick Kurt, Schimmel Paul, Ackerman Susan L
Abstract excerpt
Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. A mutation in the editing domain of alanyl tRNA synthetase (AlaRS) in Aars sti mutant mice results in an increase in the production of serine-mischarged tRNAAla and the degeneration of cerebellar Purkinje cells. Here, using positional cloning, we identified Ankrd16, a gene that acts epistatically with...
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