ACTN4 gene amplification and actinin‐4 protein overexpression drive tumour development and histological progression in a high‐grade subset of ovarian clear‐cell adenocarcinomas

Abstract excerpt

Yamamoto S, Tsuda H, Honda K, Takano M, Tamai S, Imoto I, Inazawa J, Yamada T & Matsubara O (2012) Histopathology 60,1073–1083 ACTN4 gene amplification and actinin‐4 protein overexpression drive tumour development and histological progression in a high‐grade subset of ovarian clear‐cell adenocarcinomas Aims: Actinin‐4, encoded by the ACTN4 gene located on chromosome 19q13.2, enhances cell motility by bundling the...

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