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Article

Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotype.

Cell communication and signaling : CCS - 7 Jul 2020

Yokoi Ako, Matsumoto Toshihide, Oguri Yasuko, Hasegawa Yoshinori, Tochimoto Masataka, Nakagawa Mayu, Saegusa Makoto

Abstract excerpt

BACKGROUND: We previously demonstrated that ovarian high grade serous carcinomas (OHGSeCa) and ovarian clear cell carcinomas (OCCCa) with an HNF-1β+/p53+/ARID1A+ immunophenotype were associated with the worst unfavorable prognosis. To clarify the molecular mechanisms underlying this finding, we focused on alterations in the p53 signaling pathway in these tumors. METHODS: Changes in cell phenotype and function...

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Identifiers

PMID: 32635925
DOI: 10.1186/s12964-020-00580-3
PMCID: PMC7341596

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