Article
CCR5Δ32 genotype leads to a Th2 type directed immune response in ESRD patients.
PloS one - 1 Jan 2012
Muntinghe Friso L H, Abdulahad Wayel H, Huitema Minke G, Damman Jeffrey, Seelen Marc A, Lems Simon P M, Hepkema Bouke G, Navis Gerjan, Westra Johanna
Abstract excerpt
BACKGROUND: In patients with end stage renal disease (ESRD) we observed protection from inflammation-associated mortality in CCR5Δ32 carriers, leading to CCR5 deficiency, suggesting impact of CCR5Δ32 on inflammatory processes. Animal studies have shown that CCR5 deficiency is associated with a more pronounced Th2 type immune response, suggesting that in human CCR5Δ32 carriers the immune response may be more Th2...
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