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Article

The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction.

Science signaling - 12 Jun 2012

Zou Yan, Chiu Hui, Domenger Dorothée, Chuang Chiou-Fen, Chang Chieh

Abstract excerpt

miR-125 microRNAs, such as lin-4 in Caenorhabditis elegans, were among the first microRNAs discovered, are phylogenetically conserved, and have been implicated in regulating developmental timing. Here, we showed that loss-of-function mutations in lin-4 microRNA increased axon attraction mediated by the netrin homolog UNC-6. The absence of lin-4 microRNA suppressed the axon guidance defects of anterior ventral...

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Identifiers

PMID: 22692424
DOI: 10.1126/scisignal.2002437
PMCID: PMC3670680

Genes

DCC
MADD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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