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Article

Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk.

PloS one - 1 Jan 2012

Lin I-Hsin, Ho Ming-Lin, Chen Hsuan-Yu, Lee Hong-Shen, Huang Chia-Chen, Chu Yin-Hung, Lin Shiau-Yun, Deng Ya-Ru, He Yu-Hao, Lien Yu-Hui, Hsu Chi-Wen, Wong Ruey-Hong

Abstract excerpt

Insulin-like growth factors (IGFs) are mediators of growth hormones; they have an influence on cell proliferation and differentiation. In addition, IGF-binding protein (IGFBP)-3 could suppress the mitogenic action of IGFs. Interestingly, tea polyphenols could substantially reduce IGF1 and increase IGFBP3. In this study, we evaluated the effects of smoking, green tea consumption, as well as IGF1, IGF2, and IGFBP3...

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Source

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Identifiers

PMID: 22347413
DOI: 10.1371/journal.pone.0030951
PMCID: PMC3274549

Genes

IGF1
IGFBP3
IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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