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Article

A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1.

PloS one - 1 Jan 2012

Chisholm Karen M, Aubert Sarah D, Freese Krister P, Zakian Virginia A, King Mary-Claire, Welcsh Piri L

Abstract excerpt

Alu-mediated rearrangement of tumor suppressor genes occurs frequently during carcinogenesis. In breast cancer, this mechanism contributes to loss of the wild-type BRCA1 allele in inherited disease and to loss of heterozygosity in sporadic cancer. To identify genes required for suppression of Alu-mediated recombination we performed a genomewide screen of a collection of 4672 yeast gene deletion mutants using a...

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Source

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Identifiers

PMID: 22347400
DOI: 10.1371/journal.pone.0030748
PMCID: PMC3276492

Genes

PIF1
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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