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Article

Impairment of DYRK2 augments stem-like traits by promoting KLF4 expression in breast cancer.

Oncogene - 30 Mar 2017

Mimoto R, Imawari Y, Hirooka S, Takeyama H, Yoshida K

Abstract excerpt

Whereas accumulating studies have supported the cancer stem cell theory, a specific therapy targeting a cancer stem cell subpopulation has not been established. Here, we show that dual-specificity tyrosine phosphorylation-kinase 2 (DYRK2) is a novel negative regulator for formation of breast cancer stem cells. Downregulation of DYRK2 promotes cancer stem-like traits in vitro, tumourigenesis in vivo and the...

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Topics

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Share to Cell Transformation, Neoplastic
Share to Dyrk Kinases
Share to Kruppel-Like Factor 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Neoplastic Stem Cells

Share to Protein-Tyrosine Kinases

Share to Receptors, Androgen

Share to Transcriptional Activation

Source

Identifiers

PMID: 27721402
DOI: 10.1038/onc.2016.349

Genes

DYRK2
KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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