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Article

PDCD1 polymorphism amplifies the predisposing effect conferred by CTLA4 polymorphism in chronic hepatitis B virus infection.

Human immunology - 1 Apr 2012

Zhang Guoyu, Han Qunying, Duan Shaoqiong, Li Zhu, Li Na, Zhu Qianqian, Chen Jinghong, Lv Yi, Zeng Xiaoyan, Chen Yanping, Liu Zhengwen

Abstract excerpt

Programmed cell death 1 (PDCD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) both negatively regulate the T-cell response in chronic hepatitis B virus (HBV) infection. This study determined genotypes of PDCD1 -606 G/A and +8669 G/A and CTLA4 -318 C/T and +49 A/G polymorphisms in 172 chronic HBV patients and 145 healthy controls and analyzed the interaction between these polymorphisms of the 2 genes....

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Share to Alleles
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gene Frequency

Share to Hepatitis B, Chronic

Share to Polymorphism, Single Nucleotide

Share to Programmed Cell Death 1 Receptor

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Source

Identifiers

PMID: 22342451
DOI: 10.1016/j.humimm.2012.01.013

Genes

CTLA4
PDCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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