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Article

Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression.

Scientific reports - 8 Apr 2021

Hoan Nghiem Xuan, Huyen Pham Thi Minh, Binh Mai Thanh, Trung Ngo Tat, Giang Dao Phuong, Linh Bui Thuy, Dung Dang Thi Ngoc, Pallerla Srinivas Reddy, Kremsner Peter G, Velavan Thirumalaisamy P, Bang Mai Hong, Song Le Huu

Abstract excerpt

The inhibitory effects of programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) modulates T-cell depletion. T-cell depletion is one of the key mechanisms of hepatitis B virus (HBV) persistence, in particular liver disease progression and the development of hepatocellular carcinoma (HCC). This case-control study aimed to understand the significance of PD-1 polymorphisms (PD-1.5 and PD-1.9)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

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Source

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Identifiers

PMID: 33833369
DOI: 10.1038/s41598-021-87537-9
PMCID: PMC8032722

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