Article
Association of polymorphisms of programmed cell death-1 gene with chronic hepatitis B virus infection.
Human immunology - 1 Dec 2010
Zhang Guoyu, Liu Zhengwen, Duan Shaoqiong, Han Qunying, Li Zhu, Lv Yi, Chen Jinghong, Lou Sai, Li Na
Abstract excerpt
Programmed cell death-1 (PD-1) plays a critical role in regulating T-cell function during hepatitis B virus (HBV) infection. The present study investigated the relationships between the polymorphisms of the PD-1 gene and the susceptibility to chronic HBV infection. Single nucleotide polymorphisms (SNPs) in PD-1 gene at positions -606G/A (PD-1.1) and +8669 G/A (PD-1.6) were analyzed by bidirectional PCR...
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