Therapeutic Targeting of Oncogenic Tyrosine Phosphatases.

doi:10.1158/0008-5472.CAN-17-1510

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Article

Therapeutic Targeting of Oncogenic Tyrosine Phosphatases.

Cancer research - 1 Nov 2017

Frankson Rochelle, Yu Zhi-Hong, Bai Yunpeng, Li Qinglin, Zhang Ruo-Yu, Zhang Zhong-Yin

Abstract excerpt

Protein tyrosine phosphatases (PTP) are exciting and novel targets for cancer drug discovery that work in concert with protein tyrosine kinases (PTK) in controlling cellular homeostasis. Given the activating role that some PTKs play in initiating growth factor-mediated cellular processes, PTPs are usually perceived as the negative regulators of these events and therefore tumor suppressive in nature. However,...

Topics

Animals
Antineoplastic Agents
Carcinogenesis
Humans
Molecular Targeted Therapy
Mutation
Neoplasms
Oncogenes
Protein Tyrosine Phosphatases
Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 28855209
DOI: 10.1158/0008-5472.CAN-17-1510
PMCID: PMC5827927

Genes

PRL
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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