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Article

Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist.

Science signaling - 14 Feb 2012

Bowen William S, Minns Laurie A, Johnson David A, Mitchell Thomas C, Hutton Melinda M, Evans Jay T

Abstract excerpt

In response to ligand binding to the Toll-like receptor 4 (TLR4) and myeloid differentiation-2 (MD-2) receptor complex, two major signaling pathways are activated that involve different adaptor proteins. One pathway depends on myeloid differentiation marker 88 (MyD88), which elicits proinflammatory responses, whereas the other depends on Toll-IL-1 receptor (TIR) domain-containing adaptor inducing interferon-β...

Topics

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Adaptor Proteins, Vesicular Transport
Chemokine CCL5
Chemokine CXCL10
Glucosamine
Lipid A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myeloid Differentiation Factor 88

Organophosphorus Compounds

Stereoisomerism

Source

Open in PubMed Open full text

Identifiers

PMID: 22337809
DOI: 10.1126/scisignal.2001963
PMCID: PMC3684200

Genes

TLR4
CRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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