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Targeting Toll-like Receptor 2: synthetic diacylated lipopeptides polarize equine macrophages towards a pro-inflammatory phenotype.

Frontiers in immunology - 1 Jan 2026

De Ciucis Chiara Grazia, Fruscione Floriana, Dell'Anno Filippo, Zinellu Susanna, Giaconi Emanuela, Loi Simone, Columbano Nicolò, Franzoni Giulia, Razzuoli Elisabetta

Abstract excerpt

Toll-like receptors (TLRs) are a group of pattern recognition receptors (PRRs), that play critical roles in initiating host immune defenses. TLR-2 agonists can activate innate immune cells and thus are attracting increasing attention as prophylactic and/or therapeutic agents against infectious diseases or in cancer immunotherapy. In this work, the impact of three synthetic diacylated lipopeptides...

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Cells, Cultured
Cytokines
Horses
Inflammation
Lipopeptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophage Activation

Toll-Like Receptor 2

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PMID: 41853276
DOI: 10.3389/fimmu.2026.1720816
PMCID: PMC12991996

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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