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Article

Genetic polymorphism of the iron-regulatory protein-1 and -2 genes in age-related macular degeneration.

Molecular biology reports - 1 Jun 2012

Synowiec Ewelina, Pogorzelska Magdalena, Blasiak Janusz, Szaflik Jerzy, Szaflik Jacek Pawel

Abstract excerpt

Iron can be involved in the pathogenesis of AMD through the oxidative stress because it may catalyze the Haber-Weiss and Fenton reactions converting hydrogen peroxide to free radicals, which can induce cellular damage. We hypothesized that genetic polymorphism in genes related to iron metabolism may predispose individuals to the development of AMD and therefore we checked for an association between the g.32373708...

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Identifiers

PMID: 22331484
DOI: 10.1007/s11033-012-1539-6
PMCID: PMC3334491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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