Article
Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD.
Frontiers in bioscience (Landmark edition) - 1 Jan 2013
Synowiec Ewelina, Sliwinski Tomasz, Danisz Katarzyna, Blasiak Janusz, Sklodowska Anna, Romaniuk Dorota, Watala Cezary, Szaflik Jerzy, Szaflik Jacek P
Abstract excerpt
Oxidative stress may play a role in the pathogenesis of age-related macular degeneration (AMD). In this study we examined the association between AMD risk and polymorphisms of genes encoding enzymes involved in the generation and removal of iron-mediated oxidation: NQO1 (609C> T, rs1800566), NOS3 (894G>T, rs1799983) and NFE2L2 (28312647A>G, rs6726395). We found that the G/G genotype of the rs6726395 polymorphism...
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