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Article

The A Allele of the -576G>A polymorphism of the transferrin gene is associated with the increased risk of age-related macular degeneration in smokers.

The Tohoku journal of experimental medicine - 1 Apr 2011

Wysokinski Daniel, Szaflik Jerzy, Sklodowska Anna, Kolodziejska Urszula, Dorecka Mariola, Romaniuk Dorota, Wozniak Katarzyna, Blasiak Janusz, Szaflik Jacek Pawel

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries, and its pathogenesis is underlined by genetic and environmental factors. Oxidative stress is a major environmental risk factor of AMD; namely, AMD is associated with the increased level of reactive oxygen species, which may be produced in reactions catalyzed by iron present in the retina. Therefore,...

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Identifiers

PMID: 21422745
DOI: 10.1620/tjem.223.253

Genes

TFR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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