Article

Characterisation of distinct senescent-like T cell populations during healthy and unhealthy ageing

2025-06-19

Abstract excerpt

Ageing is associated with significant immune changes, with unhealthy ageing characterised by chronic inflammation and immune dysregulation. Here we identify a population of CD8⁺ T EMRA cells during unhealthy ageing, which exhibit features of premature senescence and are regulated in part by TGFβ. These cells show impaired cytotoxic function and altered tissue distribution pattern, including an increased presence...

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Literature Corpus work: db9aa5fe-f778-5cdf-ae5a-d3ce5950b4cf
DOI: 10.1101/2025.06.16.659752

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