Article
Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function.
PloS one - 1 Jan 2012
Humphreys David T, Hynes Carly J, Patel Hardip R, Wei Grace H, Cannon Leah, Fatkin Diane, Suter Catherine M, Clancy Jennifer L, Preiss Thomas
Abstract excerpt
microRNAs (miRNAs) are critical to heart development and disease. Emerging research indicates that regulated precursor processing can give rise to an unexpected diversity of miRNA variants. We subjected small RNA from murine HL-1 cardiomyocyte cells to next generation sequencing to investigate the relevance of such diversity to cardiac biology. ∼40 million tags were mapped to known miRNA hairpin sequences as...
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