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mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity.

Briefings in bioinformatics - 2 Sept 2021

Guo Li, Li Yongsheng, Cirillo Kara M, Marick Robert A, Su Zhe, Yin Xing, Hua Xu, Mills Gordon B, Sahni Nidhi, Yi S Stephen

Abstract excerpt

MicroRNA (miRNA) is not a single sequence, but a series of multiple variants (also termed isomiRs) with sequence and expression heterogeneity. Whether and how these isoforms contribute to functional variation and complexity at the systems and network levels remain largely unknown. To explore this question systematically, we comprehensively analyzed the expression of small RNAs and their target sites to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33855356
DOI: 10.1093/bib/bbab091
PMCID: PMC8579161

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