Article
Characterization and discovery of novel miRNAs and moRNAs in JAK2V617F-mutated SET2 cells.
Blood - 29 Mar 2012
Bortoluzzi Stefania, Bisognin Andrea, Biasiolo Marta, Guglielmelli Paola, Biamonte Flavia, Norfo Ruggiero, Manfredini Rossella, Vannucchi Alessandro M
Abstract excerpt
To gain insights into a possible role of microRNAs in myeloproliferative neoplasms, we performed short RNA massive sequencing and extensive bioinformatic analysis in the JAK2V617F-mutated SET2 cell line. Overall, 652 known mature miRNAs were detected, of which 21 were highly expressed, thus being responsible of most of miRNA-mediated gene repression. microRNA putative targets were enriched in specific signaling...
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