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Article

Genetic architecture of Alzheimer's disease.

Neurobiology of disease - 1 Sept 2020

Neuner Sarah M, Tcw Julia, Goate Alison M

Abstract excerpt

Advances in genetic and genomic technologies over the last thirty years have greatly enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD). Several genes including APP, PSEN1, PSEN2, and APOE have been shown to exhibit large effects on disease susceptibility, with the remaining risk loci having much smaller effects on AD risk. Notably, common genetic variants impacting AD are not...

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Identifiers

PMID: 32565066
DOI: 10.1016/j.nbd.2020.104976
PMCID: PMC7409822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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