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Article

Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation.

Molecular biology of the cell - 15 Apr 2011

Shirai Yasuhito, Morioka Shoko, Sakuma Megumi, Yoshino Ken-Ichi, Otsuji Chihiro, Sakai Norio, Kashiwagi Kaori, Chida Kazuhiro, Shirakawa Ryutaro, Horiuchi Hisanori, Nishigori Chikako, Ueyama Takehiko, Saito Naoaki

Abstract excerpt

During differentiation, keratinocytes undergo a dramatic shape change from small and round to large and flat, in addition to production of proteins necessary for the formation of epidermis. It has been shown that protein kinase C (PKC) η is crucial for keratinocyte differentiation. However, its role in this process has yet to be fully elucidated. Here, we show that catalytic activity is not necessary for enlarged...

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Identifiers

PMID: 21346190
DOI: 10.1091/mbc.E10-09-0754
PMCID: PMC3078077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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