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Article

Seizures and neuronal damage in mice lacking vesicular zinc.

Epilepsy research - 1 Apr 2000

Cole T B, Robbins C A, Wenzel H J, Schwartzkroin P A, Palmiter R D

Abstract excerpt

Synaptically released zinc has neuromodulatory capabilities that could result in either inhibition or enhancement of neuronal excitability. To determine the net effects of vesicular zinc release in the brain in vivo, we examined seizure susceptibility and seizure-related neuronal damage in mice with targeted disruption of the gene encoding the zinc transporter, ZnT3 (ZnT3-/- mice). ZnT3-/- mice, which lack...

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PMID: 10759303
DOI: 10.1016/s0920-1211(99)00121-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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